ER: A Shift in the Night

each post gonna contain a bunch of cases i visited on ER or Clinic a week before

Sunday, November 23, 2008

Bullous Pemphigoid





Bullous pemphigoid (BP) is a chronic blistering of the skin. It ranges from mildly itchy welts to severe blisters and infection, and may affect a small area of the body or be widespread. The vast majority of those affected are elderly, but it has been seen at all ages.

It is an autoimmune disorder, meaning it is caused when the body's immune system malfunctions. The immune system is meant to defend the body against bacteria, viruses, and disease, but instead produces antibodies against healthy tissue, cells and organs. Some patients with BP have other autoimmune diseases such diabetes and rheumatoid arthritis. Various other factors have been reported to play a role in triggering BP. These include drugs (furosemide, penicillin's), mechanical trauma, and physical traumas (burns from radiation, sun or heat).

Bullous is the medical term for a large blister (a thin-walled sac filled with clear fluid). Usually the skin in BP is very itchy and large, red welts and hives may appear before or during the formation of blisters. The blisters are widespread and usually appear on the areas of the body that flex or move (flexural areas). About 15-20 percent of people with BP also develop blisters in the mouth or down the throat in the esophagus.

Because of all the variations and differing degrees of symptoms, the diagnosis must be confirmed by skin biopsy. A special skin biopsy test (a direct immunoflorecsence biopsy) may also be needed. Blood tests are usually inconclusive.

Treatment is focused on relief of symptoms and prevention of infection. Tetracycline and Minocycline antibiotics are very useful for mild to moderate disease. They do not work on bacteria, but act directly on the immune system. They can be used in combination with potent topical steroid creams for more rapid relief.

Oral steroids (prednisone, prednisolone) are the treatment of choice for severe cases. Regular visits will be needed because the dose must be adjusted frequently, and side effects must be monitored. A fairly high dose is needed initially, and once the blisters have stopped appearing, it is slowly reduced over many months or years. As steroids have some undesirable side effects, dermatologists try to reduce the dose as low as possible. If this is done too quickly, the blisters reappear.

Often, immunosuppressive agents (Immuran, Cellcept, Methotrexate, cyclophosphamide and Neoral) are used in combination with the oral steroids to allow a lower dose. Severe cases are best treated in the hospital to allow expert dressing of the wounds, and intravenous injections of the most potent treatments.

BP is a self-limiting disease that is in most cases eventually completely clears up and the treatment can be stopped. Treatment is usually needed for several years, but generally after a few months it is possible to reduce the dose of medications to reasonably low levels. BP also often has a pattern of remissions and flare-ups. It may be without symptoms for 5 or 6 years then suddenly flare up.

With careful management, most patients with BP do well. Be patient and faithfully follow your instructions, these are the keys to good results

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10 Comments:

  • At August 20, 2016 at 1:51 PM , Blogger Herbs Solutions By Nature said...

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  • At October 26, 2016 at 12:34 PM , Blogger Natural Herbs Clinic said...

    While medications are accessible to treat bullous pemphigoid, a variety of Pemphigoid Natural Treatment can also be extremely powerful.

     
  • At April 3, 2017 at 4:14 PM , Blogger Natural Herbs Clinic said...

    This comment has been removed by the author.

     
  • At April 3, 2017 at 4:18 PM , Blogger Natural Herbs Clinic said...

    Treatment of Bullous Pemphigoid helps control the itch and blisters and help the skin heal. The treatment will depend on how much of your skin is involved.

     
  • At July 20, 2017 at 12:25 PM , Blogger Margla Clerk said...

    Bullous Pemphigoid is a rare, constant condition occurring generally in elderly person. Sometime try Bullous Pemphigoid Natural Treatment include some herbal remedies and home remedies can control Bullous Pemphigoid.

     
  • At April 12, 2018 at 4:02 PM , Blogger Natural Herbs Clinic said...

    This comment has been removed by the author.

     
  • At October 6, 2018 at 2:06 PM , Blogger Natural Herbs Clinic said...

    Patients should use natural and herbal remedies for Bullous Pemphigoid Herbal Treatment . these remedies work successfully without any side effects.

     
  • At October 19, 2018 at 1:57 PM , Blogger Herbs Solutions By Nature said...


    Natural Treatment for Bullous Pemphigoid learns about the Symptoms, Causes and Diagnosis. Natural Herbal Treatment for Bullous Pemphigoid with Herbal Product Pempheton Natural Supplement for chronic autoimmune skin disease. Symptoms of Bullous Pemphigoid reduce with Natural method.

     
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